Spiramycin is a macrolide antibiotic. It is used to treat toxoplasmosis and various other infections of soft tissues. The antibacterial action involves inhibition of protein synthesis in the bacterial cell during translocation. The antibacterial spectrum comprises Gram-positive cocci and rods, Gram-negative cocci and also Legionellae, mycoplasmas, chlamydiae, some types of spirochetes, Toxoplasma gondii and Cryptosporidium sp., Enterobacteria, pseudomonads and pathogenic moulds are resistant.
Trimethoprim is a synthetic chemo-therapeutic with bacteriostatic effect against both Gram-positive and Gram-negative bacteria. It does not dissolve well in water. It is effective against bacteria such as Streptococcci, Staphylococci, E. coli, Salmonella spp., Corynebacterium spp., Pasteurella spp., and Shigella spp.. Trimethoprim is quickly and almost completely absorbed from the intestines after oral administration.